Ontology highlight
ABSTRACT:
SUBMITTER: Dick MS
PROVIDER: S-EPMC4917984 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Dick Mathias S MS Sborgi Lorenzo L Rühl Sebastian S Hiller Sebastian S Broz Petr P
Nature communications 20160622
A hallmark of inflammasome activation is the ASC speck, a micrometre-sized structure formed by the inflammasome adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD), which consists of a pyrin domain (PYD) and a caspase recruitment domain (CARD). Here we show that assembly of the ASC speck involves oligomerization of ASC(PYD) into filaments and cross-linking of these filaments by ASC(CARD). ASC mutants with a non-functional CARD only assemble filaments but not specks, a ...[more]