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Mechanisms of Disease of Eosinophilic Esophagitis.


ABSTRACT: Eosinophilic esophagitis (EoE) is a recently recognized inflammatory disease of the esophagus with clinical symptoms derived from esophageal dysfunction. The etiology of EoE is now being elucidated, and food hypersensitivity is emerging as the central cornerstone of disease pathogenesis. Herein, we present a thorough picture of the current clinical, pathologic, and molecular understanding of the disease with a focus on disease mechanisms.

SUBMITTER: Davis BP 

PROVIDER: S-EPMC4918086 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

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Mechanisms of Disease of Eosinophilic Esophagitis.

Davis Benjamin P BP   Rothenberg Marc E ME  

Annual review of pathology 20160224


Eosinophilic esophagitis (EoE) is a recently recognized inflammatory disease of the esophagus with clinical symptoms derived from esophageal dysfunction. The etiology of EoE is now being elucidated, and food hypersensitivity is emerging as the central cornerstone of disease pathogenesis. Herein, we present a thorough picture of the current clinical, pathologic, and molecular understanding of the disease with a focus on disease mechanisms. ...[more]

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