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Presenilin adopts the ClC channel fold.

ABSTRACT: Presenilin is an integral membrane aspartate protease that regulates cellular processes by cleaving proteins within the cell membrane. The recent crystal structure of presenilin reveals a conspicuous pore in a bundle of nine ?-helices, which was originally thought to adopt a novel protein fold. However, here I show that the presenilin fold is a variant of the ClC chloride channel/transporter fold. This observation may have important implications for presenilin's postulated biological role as a calcium leak channel.

SUBMITTER: Theobald DL

PROVIDER: S-EPMC4918416 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

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Presenilin adopts the ClC channel fold.

Theobald Douglas L DL

Protein science : a publication of the Protein Society 20160323 7

Presenilin is an integral membrane aspartate protease that regulates cellular processes by cleaving proteins within the cell membrane. The recent crystal structure of presenilin reveals a conspicuous pore in a bundle of nine α-helices, which was originally thought to adopt a novel protein fold. However, here I show that the presenilin fold is a variant of the ClC chloride channel/transporter fold. This observation may have important implications for presenilin's postulated biological role as a c ...[more]

PMID: 26971579

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