Ontology highlight
ABSTRACT:
SUBMITTER: Muff-Luett M
PROVIDER: S-EPMC4918710 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Journal of pediatric genetics 20160223 1
The complement-mediated renal diseases are a group of ultra-rare renal diseases that disproportionately affect children and young adults and frequently lead to irreversible renal failure. Genetic mutations in alternate pathway of complement genes are pathomechanistically involved in a significant number of these unique diseases. Here, we review our current understanding of the role of genetics in the primary complement-mediated renal diseases affecting children, with a focus on atypical hemolyti ...[more]