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Daily access to sucrose impairs aspects of spatial memory tasks reliant on pattern separation and neural proliferation in rats.

ABSTRACT: High sugar diets reduce hippocampal neurogenesis, which is required for minimizing interference between memories, a process that involves "pattern separation." We provided rats with 2 h daily access to a sucrose solution for 28 d and assessed their performance on a spatial memory task. Sucrose consuming rats discriminated between objects in novel and familiar locations when there was a large spatial separation between the objects, but not when the separation was smaller. Neuroproliferation markers in the dentate gyrus of the sucrose-consuming rats were reduced relative to controls. Thus, sucrose consumption impaired aspects of spatial memory and reduced hippocampal neuroproliferation.

SUBMITTER: Reichelt AC

PROVIDER: S-EPMC4918785 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

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Daily access to sucrose impairs aspects of spatial memory tasks reliant on pattern separation and neural proliferation in rats.

Reichelt Amy C AC Morris Margaret J MJ Westbrook Reginald Frederick RF

Learning & memory (Cold Spring Harbor, N.Y.) 20160617 7

High sugar diets reduce hippocampal neurogenesis, which is required for minimizing interference between memories, a process that involves "pattern separation." We provided rats with 2 h daily access to a sucrose solution for 28 d and assessed their performance on a spatial memory task. Sucrose consuming rats discriminated between objects in novel and familiar locations when there was a large spatial separation between the objects, but not when the separation was smaller. Neuroproliferation marke ...[more]

PMID: 27317199

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