Lipoprotein (a): impact by ethnicity and environmental and medical conditions.
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ABSTRACT:
SUBMITTER: Enkhmaa B
PROVIDER: S-EPMC4918859 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Publications
Lipoprotein (a): impact by ethnicity and environmental and medical conditions.
Enkhmaa Byambaa B Anuurad Erdembileg E Berglund Lars L
Journal of lipid research 20151204 7
Levels of lipoprotein (a) [Lp(a)], a complex between an LDL-like lipid moiety containing one copy of apoB, and apo(a), a plasminogen-derived carbohydrate-rich hydrophilic protein, are primarily genetically regulated. Although stable intra-individually, Lp(a) levels have a skewed distribution inter-individually and are strongly impacted by a size polymorphism of the LPA gene, resulting in a variable number of kringle IV (KIV) units, a key motif of apo(a). The variation in KIV units is a strong pr ...[more]
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