Ontology highlight
ABSTRACT:
SUBMITTER: Gutowski SM
PROVIDER: S-EPMC4918902 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Gutowski Stacie M SM Templeman Kellie L KL South Antoinette B AB Gaulding Jeffrey C JC Shoemaker James T JT LaPlaca Michelle C MC Bellamkonda Ravi V RV Lyon L Andrew LA García Andrés J AJ
Journal of biomedical materials research. Part A 20130625 5
The performance of neural electrodes implanted in the brain is often limited by host response in the surrounding brain tissue, including astrocytic scar formation, neuronal cell death, and inflammation around the implant. We applied conformal microgel coatings to silicon neural electrodes and examined host responses to microgel-coated and uncoated electrodes following implantation in the rat brain. In vitro analyses demonstrated significantly reduced astrocyte and microglia adhesion to microgel- ...[more]