Ontology highlight
ABSTRACT:
SUBMITTER: Noubouossie D
PROVIDER: S-EPMC4919240 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Blood reviews 20151224 4
Sickle cell disease (SCD) is a hypercoagulable state. Patients exhibit increased platelet activation, high plasma levels of markers of thrombin generation, depletion of natural anticoagulant proteins, abnormal activation of the fibrinolytic system, and increased tissue factor expression, even in the non-crisis "steady state." Furthermore, SCD is characterized by an increased risk of thrombotic complications. The pathogenesis of coagulation activation in SCD appears to be multi-factorial, with co ...[more]