Ontology highlight
ABSTRACT:
SUBMITTER: Ramakrishnan S
PROVIDER: S-EPMC4919544 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Ramakrishnan Saravanan S Pokhrel Srijana S Palani Sowmiya S Pflueger Christian C Parnell Timothy J TJ Cairns Bradley R BR Bhaskara Srividya S Chandrasekharan Mahesh B MB
Nature communications 20160621
Histone H3K4 methylation is connected to gene transcription from yeast to humans, but its mechanistic roles in transcription and chromatin dynamics remain poorly understood. We investigated the functions for Set1 and Jhd2, the sole H3K4 methyltransferase and H3K4 demethylase, respectively, in S. cerevisiae. Here, we show that Set1 and Jhd2 predominantly co-regulate genome-wide transcription. We find combined activities of Set1 and Jhd2 via H3K4 methylation contribute to positive or negative tran ...[more]