Cell Surface Access Is Modulated by Tethered Bottlebrush Proteoglycans.
Ontology highlight
ABSTRACT:
SUBMITTER: Chang PS
PROVIDER: S-EPMC4919654 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Publications
Cell Surface Access Is Modulated by Tethered Bottlebrush Proteoglycans.
Chang Patrick S PS McLane Louis T LT Fogg Ruth R Scrimgeour Jan J Temenoff Johnna S JS Granqvist Anna A Curtis Jennifer E JE
Biophysical journal 20160601 12
The hyaluronan-rich pericellular matrix (PCM) plays physical and chemical roles in biological processes ranging from brain plasticity, to adhesion-dependent phenomena such as cell migration, to the onset of cancer. This study investigates how the spatial distribution of the large negatively charged bottlebrush proteoglycan, aggrecan, impacts PCM morphology and cell surface access. The highly localized pericellular milieu limits transport of nanoparticles in a size-dependent fashion and sequester ...[more]
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