Ontology highlight
ABSTRACT:
SUBMITTER: Heman-Ackah SM
PROVIDER: S-EPMC4920027 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Heman-Ackah Sabrina Mahalia SM Bassett Andrew Roger AR Wood Matthew John Andrew MJ
Scientific reports 20160624
The ability to reprogram adult somatic cells into induced pluripotent stem cells (iPSCs) and the subsequent development of protocols for their differentiation into disease-relevant cell types have enabled in-depth molecular analyses of multiple disease states as hitherto impossible. Neurons differentiated from patient-specific iPSCs provide a means to recapitulate molecular phenotypes of neurodegenerative diseases in vitro. However, it remains challenging to conduct precise manipulations of gene ...[more]