Ontology highlight
ABSTRACT:
SUBMITTER: Grant SS
PROVIDER: S-EPMC4920728 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Cell chemical biology 20160616 6
Successful treatment of Mycobacterium tuberculosis infection typically requires a complex regimen administered over at least 6 months. Interestingly, many of the antibiotics used to treat M. tuberculosis are prodrugs that require intracellular activation. Here, we describe three small molecules, active against both replicating and non-replicating M. tuberculosis, that require activation by Baeyer-Villiger monooxygenases (BVMOs). Two molecules require BVMO EthA (Rv3854c) for activation and the th ...[more]