Characterization of the Intermediate in and Identification of the Repair Mechanism of (6-4) Photolesions by Photolyases.
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ABSTRACT:
SUBMITTER: Faraji S
PROVIDER: S-EPMC4921128 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
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Characterization of the Intermediate in and Identification of the Repair Mechanism of (6-4) Photolesions by Photolyases.
Faraji Shirin S Zhong Dongping D Dreuw Andreas A
Angewandte Chemie (International ed. in English) 20160321 17
Quantum mechanics/molecular mechanics calculations are employed to assign previously recorded experimental spectroscopic signatures of the intermediates occurring during the photo-induced repair of (6-4) photolesions by photolyases to specific molecular structures. Based on this close comparison of experiment and theory it is demonstrated that the acting repair mechanism involves proton transfer from the protonated His365 to the N3' nitrogen of the lesion, which proceeds simultaneously with intr ...[more]
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