Ontology highlight
ABSTRACT:
SUBMITTER: Posch C
PROVIDER: S-EPMC4921268 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Posch Christian C Vujic Igor I Monshi Babak B Sanlorenzo Martina M Weihsengruber Felix F Rappersberger Klemens K Ortiz-Urda Susana S
The Journal of investigative dermatology 20160507 7
Up to 18% of melanomas harbor mutations in the neuroblastoma rat-sarcoma homolog (NRAS). Yet, decades of research aimed to interfere with oncogenic RAS signaling have been largely disappointing and have not resulted in meaningful clinical outputs. Recent advances in disease modeling, structural biology, and an improved understanding of RAS cycling as well as RAS signaling networks have renewed hope for developing strategies to selectively block hyperactive RAS function. This review discusses dir ...[more]