Dataset Information

Genes Involved in Interleukin-1 Receptor Type II Activities Are Associated With Asthmatic Phenotypes.

ABSTRACT:

Purpose

Interleukin-1 (IL-1) plays a key role in inflammation and immunity and its decoy receptor, IL-1R2, has been implicated in transcriptomic and genetic studies of asthma.

Methods

Two large asthma family collections, the French-Canadian Saguenay-Lac-St-Jean (SLSJ) study and the French Epidemiological Study on the Genetics and Environment of Asthma (EGEA), were used to investigate the association of SNPs in 10 genes that modulate IL-1R2 activities with asthma, allergic asthma, and atopy. Gene-gene interactions were also tested.

Results

One SNP in BACE2 was associated with allergic asthma in the SLSJ study and replicated in the EGEA study before statistical correction for multiple testing. Additionally, two SNPs in the MMP2 gene were replicated in both studies prior to statistical correction and reached significance in the combined analysis. Moreover, three gene-gene interactions also survived statistical correction in the combined analyses (BACE1-IL1RAP in asthma and allergic asthma and IL1R1-IL1RAP in atopy).

Conclusions

Our results highlight the relevance of genes involved in the IL-1R2 activity in the context of asthma and asthma-related traits.

SUBMITTER: Madore AM

PROVIDER: S-EPMC4921702 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

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Publications

Genes Involved in Interleukin-1 Receptor Type II Activities Are Associated With Asthmatic Phenotypes.

Madore Anne Marie AM Vaillancourt Vanessa T VT Bouzigon Emmanuelle E Sarnowski Chloé C Monier Florent F Dizier Marie Hélène MH Demenais Florence F Laprise Catherine C

Allergy, asthma & immunology research 20160901 5

<h4>Purpose</h4>Interleukin-1 (IL-1) plays a key role in inflammation and immunity and its decoy receptor, IL-1R2, has been implicated in transcriptomic and genetic studies of asthma.<h4>Methods</h4>Two large asthma family collections, the French-Canadian Saguenay-Lac-St-Jean (SLSJ) study and the French Epidemiological Study on the Genetics and Environment of Asthma (EGEA), were used to investigate the association of SNPs in 10 genes that modulate IL-1R2 activities with asthma, allergic asthma, ...[more]

PMID: 27334786

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Dataset Information

Genes Involved in Interleukin-1 Receptor Type II Activities Are Associated With Asthmatic Phenotypes.

Purpose

Methods

Results

Conclusions

Publications

Genes Involved in Interleukin-1 Receptor Type II Activities Are Associated With Asthmatic Phenotypes.

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