Ontology highlight
ABSTRACT:
SUBMITTER: Legeay S
PROVIDER: S-EPMC4921870 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Legeay Samuel S Clere Nicolas N Hilairet Grégory G Do Quoc-Tuan QT Bernard Philippe P Quignard Jean-François JF Apaire-Marchais Véronique V Lapied Bruno B Faure Sébastien S
Scientific reports 20160627
The insect repellent N,N-diethyl-m-toluamide (DEET) has been reported to inhibit AChE (acetylcholinesterase) and to possess potential carcinogenic properties with excessive vascularization. In the present paper, we demonstrate that DEET specifically stimulates endothelial cells that promote angiogenesis which increases tumor growth. DEET activates cellular processes that lead to angiogenesis including proliferation, migration and adhesion. This is associated with an enhancement of NO production ...[more]