TMEM16F Regulates Spinal Microglial Function in Neuropathic Pain States.
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ABSTRACT:
SUBMITTER: Batti L
PROVIDER: S-EPMC4921873 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Publications
TMEM16F Regulates Spinal Microglial Function in Neuropathic Pain States.
Batti Laura L Sundukova Mayya M Murana Emanuele E Pimpinella Sofia S De Castro Reis Fernanda F Pagani Francesca F Wang Hong H Pellegrino Eloisa E Perlas Emerald E Di Angelantonio Silvia S Ragozzino Davide D Heppenstall Paul A PA
Cell reports 20160601 12
Neuropathic pain is a widespread chronic pain state that results from injury to the nervous system. Spinal microglia play a causative role in the pathogenesis of neuropathic pain through secretion of growth factors and cytokines. Here, we investigated the contribution of TMEM16F, a protein that functions as a Ca(2+)-dependent ion channel and a phospholipid scramblase, to microglial activity during neuropathic pain. We demonstrate that mice with a conditional ablation of TMEM16F in microglia do n ...[more]
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