Ontology highlight
ABSTRACT:
SUBMITTER: Takahashi K
PROVIDER: S-EPMC4922138 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Takahashi Kazunobu K Matouschek Andreas A Inobe Tomonao T
ACS chemical biology 20150821 11
Methods for regulating the concentrations of specific cellular proteins are valuable tools for biomedical studies. Artificial regulation of protein degradation by the proteasome is receiving increasing attention. Efficient proteasomal protein degradation requires a degron with two components: a ubiquitin tag that is recognized by the proteasome and a disordered region at which the proteasome engages the substrate and initiates degradation. Here we show that degradation rates can be regulated by ...[more]