Homologous Recombination Repair Polymorphisms and the Risk for Osteosarcoma.

ABSTRACT:

Background

DNA repair mechanisms are essential for maintaining genome stability, and genetic variability in DNA repair genes may contribute to cancer susceptibility. Our aim was to evaluate the influence of polymorphisms in the homologous recombination repair genes XRCC3, RAD51, and NBN on the risk for osteosarcoma.

Methods

In total, 79 osteosarcoma cases and 373 controls were genotyped for eight single nucleotide polymorphisms (SNPs) in XRCC3, RAD51, and NBN. Logistic regression was used to determine the association of these SNPs with risk for osteosarcoma.

Results

None of the investigated SNPs was associated with risk for osteosarcoma in the whole cohort of patients, however, in patients diagnosed before the age of thirty ye

SUBMITTER: Goricar K 

PROVIDER: S-EPMC4922323 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature