Feasibility and Effectiveness of a Novel Exoskeleton for an Infant With Arm Movement Impairments.
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ABSTRACT:
SUBMITTER: Babik I
PROVIDER: S-EPMC4922496 | biostudies-literature | 2016 Fall
REPOSITORIES: biostudies-literature
Publications
Feasibility and Effectiveness of a Novel Exoskeleton for an Infant With Arm Movement Impairments.
Babik Iryna I Kokkoni Elena E Cunha Andrea B AB Galloway James Cole JC Rahman Tariq T Lobo Michele A MA
Pediatric physical therapy : the official publication of the Section on Pediatrics of the American Physical Therapy Association 20160901 3
<h4>Purpose</h4>To determine whether a novel exoskeletal device (Pediatric-Wilmington Robotic Exoskeleton [P-WREX]) is feasible and effective for intervention to improve reaching and object interaction for an infant with arm movement impairments.<h4>Methods</h4>An 8-month old infant with arthrogryposis was followed up every 2 weeks during a 1-month baseline, 3-month intervention, and 1-month postintervention. At each visit, reaching and looking behaviors were assessed.<h4>Results</h4>Within sess ...[more]
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Project description:The process by which neural circuitry in the brain plans and executes movements is not well understood. Until recently, most available data were limited either to single-neuron electrophysiological recordings or to measures of aggregate field or metabolism. Neither approach reveals how individual neurons' activities are coordinated within the population, and thus inferences about how the neural circuit forms a motor plan for an upcoming movement have been indirect. Here we build on recent advances in the measurement and description of population activity to frame and test an "initial condition hypothesis" of arm movement preparation and initiation. This hypothesis leads to a model in which the timing of movements may be predicted on each trial using neurons' moment-by-moment firing rates and rates of change of those rates. Using simultaneous microelectrode array recordings from premotor cortex of monkeys performing delayed-reach movements, we compare such single-trial predictions to those of other theories. We show that our model can explain approximately 4-fold more arm-movement reaction-time variance than the best alternative method. Thus, the initial condition hypothesis elucidates a view of the relationship between single-trial preparatory neural population dynamics and single-trial behavior.
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