Ontology highlight
ABSTRACT:
SUBMITTER: Corrales L
PROVIDER: S-EPMC4922692 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Corrales Leticia L McWhirter Sarah M SM Dubensky Thomas W TW Gajewski Thomas F TF
The Journal of clinical investigation 20160701 7
A major subset of human cancers shows evidence for spontaneous adaptive immunity, which is reflected by the presence of infiltrating CD8+ T cells specific for tumor antigens within the tumor microenvironment. This observation has raised the question of which innate immune sensing pathway might detect the presence of cancer and lead to a natural adaptive antitumor immune response in the absence of exogenous infectious pathogens. Evidence for a critical functional role for type I IFNs led to inter ...[more]