Ontology highlight
ABSTRACT:
SUBMITTER: Younes SA
PROVIDER: S-EPMC4922693 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Younes Souheil-Antoine SA Freeman Michael L ML Mudd Joseph C JC Shive Carey L CL Reynaldi Arnold A Panigrahi Soumya S Estes Jacob D JD Deleage Claire C Lucero Carissa C Anderson Jodi J Schacker Timothy W TW Davenport Miles P MP McCune Joseph M JM Hunt Peter W PW Lee Sulggi A SA Serrano-Villar Sergio S Debernardo Robert L RL Jacobson Jeffrey M JM Canaday David H DH Sekaly Rafick-Pierre RP Rodriguez Benigno B Sieg Scott F SF Lederman Michael M MM
The Journal of clinical investigation 20160620 7
In HIV-1-infected patients, increased numbers of circulating CD8+ T cells are linked to increased risk of morbidity and mortality. Here, we identified a bystander mechanism that promotes CD8 T cell activation and expansion in untreated HIV-1-infected patients. Compared with healthy controls, untreated HIV-1-infected patients have an increased population of proliferating, granzyme B+, CD8+ T cells in circulation. Vβ expression and deep sequencing of CDR3 revealed that in untreated HIV-1 infection ...[more]