Ontology highlight
ABSTRACT:
SUBMITTER: Souma T
PROVIDER: S-EPMC4922711 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Souma Tomokazu T Tompson Stuart W SW Thomson Benjamin R BR Siggs Owen M OM Kizhatil Krishnakumar K Yamaguchi Shinji S Feng Liang L Limviphuvadh Vachiranee V Whisenhunt Kristina N KN Maurer-Stroh Sebastian S Yanovitch Tammy L TL Kalaydjieva Luba L Azmanov Dimitar N DN Finzi Simone S Mauri Lucia L Javadiyan Shahrbanou S Souzeau Emmanuelle E Zhou Tiger T Hewitt Alex W AW Kloss Bethany B Burdon Kathryn P KP Mackey David A DA Allen Keri F KF Ruddle Jonathan B JB Lim Sing-Hui SH Rozen Steve S Tran-Viet Khanh-Nhat KN Liu Xiaorong X John Simon S Wiggs Janey L JL Pasutto Francesca F Craig Jamie E JE Jin Jing J Quaggin Susan E SE Young Terri L TL
The Journal of clinical investigation 20160606 7
Primary congenital glaucoma (PCG) is a devastating eye disease and an important cause of childhood blindness worldwide. In PCG, defects in the anterior chamber aqueous humor outflow structures of the eye result in elevated intraocular pressure (IOP); however, the genes and molecular mechanisms involved in the etiology of these defects have not been fully characterized. Previously, we observed PCG-like phenotypes in transgenic mice that lack functional angiopoietin-TEK signaling. Herein, we ident ...[more]