Ontology highlight
ABSTRACT:
SUBMITTER: DeCaen PG
PROVIDER: S-EPMC4922860 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
eLife 20160627
Native PKD2-L1 channel subunits are present in primary cilia and other restricted cellular spaces. Here we investigate the mechanism for the channel's unusual regulation by external calcium, and rationalize this behavior to its specialized function. We report that the human PKD2-L1 selectivity filter is partially selective to calcium ions (Ca(2+)) moving into the cell, but blocked by high internal Ca(2+)concentrations, a unique feature of this transient receptor potential (TRP) channel family me ...[more]