Ontology highlight
ABSTRACT:
SUBMITTER: Wu C
PROVIDER: S-EPMC4923333 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Wu Connie C Shopsowitz Kevin E KE Hammond Paula T PT
Molecular therapy : the journal of the American Society of Gene Therapy 20160407 6
RNA interference (RNAi) provides a versatile therapeutic approach via silencing of specific genes, particularly undruggable targets in cancer and other diseases. However, challenges in the delivery of small interfering RNA (siRNA) have hampered clinical translation. Polymeric or periodic short hairpin RNAs (p-shRNAs)-synthesized by enzymatic amplification of circular DNA-are a recent development that can potentially address these delivery barriers by showing improved stability and complexation t ...[more]