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Circular Helix-Like Curve: An Effective Tool of Biological Sequence Analysis and Comparison.


ABSTRACT: This paper constructed a novel injection from a DNA sequence to a 3D graph, named circular helix-like curve (CHC). The presented graphical representation is available for visualizing characterizations of a single DNA sequence and identifying similarities and differences among several DNAs. A 12-dimensional vector extracted from CHC, as a numerical characterization of CHC, was applied to analyze phylogenetic relationships of 11 species, 74 ribosomal RNAs, 48 Hepatitis E viruses, and 18 eutherian mammals, respectively. Successful experiments illustrated that CHC is an effective tool of biological sequence analysis and comparison.

SUBMITTER: Li Y 

PROVIDER: S-EPMC4923644 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Circular Helix-Like Curve: An Effective Tool of Biological Sequence Analysis and Comparison.

Li Yushuang Y   Xiao Wenli W  

Computational and mathematical methods in medicine 20160614


This paper constructed a novel injection from a DNA sequence to a 3D graph, named circular helix-like curve (CHC). The presented graphical representation is available for visualizing characterizations of a single DNA sequence and identifying similarities and differences among several DNAs. A 12-dimensional vector extracted from CHC, as a numerical characterization of CHC, was applied to analyze phylogenetic relationships of 11 species, 74 ribosomal RNAs, 48 Hepatitis E viruses, and 18 eutherian  ...[more]

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