Ontology highlight
ABSTRACT:
SUBMITTER: Spalinger MR
PROVIDER: S-EPMC4924425 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Spalinger Marianne R MR Scharl Michael M
United European gastroenterology journal 20150806 3
Inflammatory bowel disease represents a chronic intestinal inflammation. Recent knowledge suggests a crucial role for genetic, immunological and bacterial factors in inflammatory bowel disease pathogenesis. Variations within the gene locus encoding PTPN22 have been associated with inflammatory bowel disease. PTPN22 is critically involved in controlling immune cell activation and thereby plays an important role in maintaining intestinal homeostasis. Although in B and T cells the mechanism showing ...[more]