Ontology highlight
ABSTRACT:
SUBMITTER: Gao H
PROVIDER: S-EPMC4924521 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Langmuir : the ACS journal of surfaces and colloids 20150615 24
Most organs and tissues are composed of more than one type of cell that is spatially separated and located in different regions. This study used a microgrooved poly(lactic-co-glycolic acid) (PLGA) substrate to guide two types of cocultured cells to two spatially separated regions. Specifically, PC12 pheochromocytoma cells are guided to the inside of microgrooves, whereas NIH3T3 fibroblasts are guided to the ridge area in between neighboring parallel microgrooves. In addition, the microgrooved st ...[more]