Ontology highlight
ABSTRACT:
SUBMITTER: Galanie S
PROVIDER: S-EPMC4924617 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Galanie Stephanie S Thodey Kate K Trenchard Isis J IJ Filsinger Interrante Maria M Smolke Christina D CD
Science (New York, N.Y.) 20150813 6252
Opioids are the primary drugs used in Western medicine for pain management and palliative care. Farming of opium poppies remains the sole source of these essential medicines, despite diverse market demands and uncertainty in crop yields due to weather, climate change, and pests. We engineered yeast to produce the selected opioid compounds thebaine and hydrocodone starting from sugar. All work was conducted in a laboratory that is permitted and secured for work with controlled substances. We comb ...[more]