Ontology highlight
ABSTRACT:
SUBMITTER: Yu M
PROVIDER: S-EPMC4924675 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Yu Mengchao M Liang Hongwei H Fu Zheng Z Wang Xueliang X Liao Zhicong Z Zhou Yong Y Liu Yanqing Y Wang Yanbo Y Hong Yeting Y Zhou Xinyan X Yan Xin X Yu Min M Ma Miao M Zhang Weijie W Guo Baoliang B Zhang Jianguo J Zen Ke K Zhang Chen-Yu CY Wang Tao T Zhang Qipeng Q Chen Xi X
Oncotarget 20160301 12
BRCA1-associated protein-1 (BAP1) is an important nuclear-localized deubiquitinating enzyme that serves as a tumor suppressor in lung cancer; however, its function and its regulation are largely unknown. In this study, we found that BAP1 protein levels were dramatically diminished in lung cancer tissues while its mRNA levels did not differ significantly, suggesting that a post-transcriptional mechanism was involved in BAP1 regulation. Because microRNAs (miRNAs) are powerful post-transcriptional ...[more]