Ontology highlight
ABSTRACT:
SUBMITTER: Weller M
PROVIDER: S-EPMC4924768 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Weller Michael M Nabors Louis Burt LB Gorlia Thierry T Leske Henning H Rushing Elisabeth E Bady Pierre P Hicking Christine C Perry James J Hong Yong-Kil YK Roth Patrick P Wick Wolfgang W Goodman Simon L SL Hegi Monika E ME Picard Martin M Moch Holger H Straub Josef J Stupp Roger R
Oncotarget 20160301 12
Integrins αvβ3 and αvβ5 regulate angiogenesis and invasiveness in cancer, potentially by modulating activation of the transforming growth factor (TGF)-β pathway. The randomized phase III CENTRIC and phase II CORE trials explored the integrin inhibitor cilengitide in patients with newly diagnosed glioblastoma with versus without O6-methylguanine DNA methyltransferase (MGMT) promoter methylation. These trials failed to meet their primary endpoints.Immunohistochemistry was used to assess the levels ...[more]