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Familial Pelger-Huet Anomaly.

ABSTRACT: Pelger-Huet anomaly is usually autosomal dominant, although it is likely that new mutations are common. This condition is characterized by granulocytes that are either bilobed or completely unsegmented. Here is a report of a 46 year old Indian lady who presented with fever to the hospital and on evaluation, her peripheral blood smear showed extreme hypolobation of granulocytes. Along with normal appearing neutrophils there were many neutrophils with bilobed and single monolobated nuclei which accounted for 82 % of the neutrophils. After identifying these neutrophilic abnormalities which were suggestive of Pelgeroid changes, the other family members were also screened and were found to be having similar morphologic abnormalities in granulocytes. As these changes were evident in granulocytic leucocytes of the patient as well as her mother, both her sisters and her son, with exception of her brother, the diagnosis of familial Pelger-Huet Anomaly was considered in this case.

SUBMITTER: Shah SS

PROVIDER: S-EPMC4925487 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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Familial Pelger-Huet Anomaly.

Shah Samir S SS Parikh Rupali S RS Vaswani Lakshmi P LP Divkar Rajeshree R

Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion 20150125 Suppl 1

Pelger-Huet anomaly is usually autosomal dominant, although it is likely that new mutations are common. This condition is characterized by granulocytes that are either bilobed or completely unsegmented. Here is a report of a 46 year old Indian lady who presented with fever to the hospital and on evaluation, her peripheral blood smear showed extreme hypolobation of granulocytes. Along with normal appearing neutrophils there were many neutrophils with bilobed and single monolobated nuclei which ac ...[more]

PMID: 27408433

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