Ontology highlight
ABSTRACT:
SUBMITTER: Tuncbag N
PROVIDER: S-EPMC4926112 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Tuncbag Nurcan N Milani Pamela P Pokorny Jenny L JL Johnson Hannah H Sio Terence T TT Dalin Simona S Iyekegbe Dennis O DO White Forest M FM Sarkaria Jann N JN Fraenkel Ernest E
Scientific reports 20160629
Glioblastoma is the most aggressive type of malignant human brain tumor. Molecular profiling experiments have revealed that these tumors are extremely heterogeneous. This heterogeneity is one of the principal challenges for developing targeted therapies. We hypothesize that despite the diverse molecular profiles, it might still be possible to identify common signaling changes that could be targeted in some or all tumors. Using a network modeling approach, we reconstruct the altered signaling pat ...[more]