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Recent Advances in Developing Small Molecules Targeting Nucleic Acid.

ABSTRACT: Nucleic acids participate in a large number of biological processes. However, current approaches for small molecules targeting protein are incompatible with nucleic acids. On the other hand, the lack of crystallization of nucleic acid is the limiting factor for nucleic acid drug design. Because of the improvements in crystallization in recent years, a great many structures of nucleic acids have been reported, providing basic information for nucleic acid drug discovery. This review focuses on the discovery and development of small molecules targeting nucleic acids.

SUBMITTER: Wang M

PROVIDER: S-EPMC4926330 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

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Recent Advances in Developing Small Molecules Targeting Nucleic Acid.

Wang Maolin M Yu Yuanyuan Y Liang Chao C Lu Aiping A Zhang Ge G

International journal of molecular sciences 20160530 6

Nucleic acids participate in a large number of biological processes. However, current approaches for small molecules targeting protein are incompatible with nucleic acids. On the other hand, the lack of crystallization of nucleic acid is the limiting factor for nucleic acid drug design. Because of the improvements in crystallization in recent years, a great many structures of nucleic acids have been reported, providing basic information for nucleic acid drug discovery. This review focuses on the ...[more]

PMID: 27248995

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