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Spatial Partitioning of miRNAs Is Related to Sequence Similarity in Overall Transcriptome.

ABSTRACT: RNAs have been shown to exhibit differential enrichment between nuclear, cytoplasmic, and exosome fractions. A current fundamental question asks why non-coding RNA partition into different spatial compartments. We report on the analysis of cellular compartment models with miRNA data sources for spatial-mechanistic modeling to address the broad area of multi-scalar cellular communication by miRNAs. We show that spatial partitioning of miRNAs is related to sequence similarity to the overall transcriptome. This has broad implications in biological informatics for gene regulation and provides a deeper understanding of nucleotide sequence structure and RNA language meaning for human pathologies resulting from changes in gene expression.

SUBMITTER: Seffens W

PROVIDER: S-EPMC4926364 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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Spatial Partitioning of miRNAs Is Related to Sequence Similarity in Overall Transcriptome.

Seffens William W Abebe Fisseha F Evans Chad C Wang Xiao-Qian XQ

International journal of molecular sciences 20160608 6

RNAs have been shown to exhibit differential enrichment between nuclear, cytoplasmic, and exosome fractions. A current fundamental question asks why non-coding RNA partition into different spatial compartments. We report on the analysis of cellular compartment models with miRNA data sources for spatial-mechanistic modeling to address the broad area of multi-scalar cellular communication by miRNAs. We show that spatial partitioning of miRNAs is related to sequence similarity to the overall transc ...[more]

PMID: 27338352

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