Ontology highlight
ABSTRACT:
SUBMITTER: Barata TS
PROVIDER: S-EPMC4926387 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Barata Teresa S TS Zhang Cheng C Dalby Paul A PA Brocchini Steve S Zloh Mire M
International journal of molecular sciences 20160601 6
Protein formulation development relies on the selection of excipients that inhibit protein-protein interactions preventing aggregation. Empirical strategies involve screening many excipient and buffer combinations using force degradation studies. Such methods do not readily provide information on intermolecular interactions responsible for the protective effects of excipients. This study describes a molecular docking approach to screen and rank interactions allowing for the identification of pro ...[more]