Immune Mechanisms in Myelodysplastic Syndrome.
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ABSTRACT:
SUBMITTER: Glenthoj A
PROVIDER: S-EPMC4926477 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Publications
Immune Mechanisms in Myelodysplastic Syndrome.
Glenthøj Andreas A Ørskov Andreas Due AD Hansen Jakob Werner JW Hadrup Sine Reker SR O'Connell Casey C Grønbæk Kirsten K
International journal of molecular sciences 20160615 6
Myelodysplastic syndrome (MDS) is a spectrum of diseases, characterized by debilitating cytopenias and a propensity of developing acute myeloid leukemia. Comprehensive sequencing efforts have revealed a range of mutations characteristic, but not specific, of MDS. Epidemiologically, autoimmune diseases are common in patients with MDS, fueling hypotheses of common etiological mechanisms. Both innate and adaptive immune pathways are overly active in the hematopoietic niche of MDS. Although supporti ...[more]
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