Effect of age at onset on cortical thickness and cognition in posterior cortical atrophy.
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ABSTRACT:
SUBMITTER: Suarez-Gonzalez A
PROVIDER: S-EPMC4926954 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Publications
Effect of age at onset on cortical thickness and cognition in posterior cortical atrophy.
Suárez-González Aida A Lehmann Manja M Shakespeare Timothy J TJ Yong Keir X X KXX Paterson Ross W RW Slattery Catherine F CF Foulkes Alexander J M AJM Rabinovici Gil D GD Gil-Néciga Eulogio E Roldán-Lora Florinda F Schott Jonathan M JM Fox Nick C NC Crutch Sebastian J SJ
Neurobiology of aging 20160425
Age at onset (AAO) has been shown to influence the phenotype of Alzheimer's disease (AD), but how it affects atypical presentations of AD remains unknown. Posterior cortical atrophy (PCA) is the most common form of atypical AD. In this study, we aimed to investigate the effect of AAO on cortical thickness and cognitive function in 98 PCA patients. We used Freesurfer (v5.3.0) to compare cortical thickness with AAO both as a continuous variable, and by dichotomizing the groups based on median age ...[more]
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