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Significant grey matter changes in a region of the orbitofrontal cortex in healthy participants predicts emotional dysregulation.


ABSTRACT: The traditional concept of 'categorical' psychiatric disorders has been challenged as many of the symptoms display a continuous distribution in the general population. We suggest that this is the case for emotional dysregulation, a key component in several categorical psychiatric disorder constructs. We used voxel-based magnetic resonance imaging morphometry in healthy human subjects (n?=?87) to study how self-reported subclinical symptoms associated with emotional dysregulation relate to brain regions assumed to be critical for emotion regulation. To measure a pure emotional dysregulation, we also corrected for subclinical symptoms of non-emotional attentional dysregulation. We show that such subclinical emotional symptoms correlate negatively with the grey matter volume of lateral orbitofrontal cortex bilaterally-a region assumed to be critical for emotion regulation and dysfunctional in psychiatric disorders involving emotional dysregulation. Importantly, this effect is mediated both by a decrease in volume associated with emotional dysregulation and an increase in volume due to non-emotional attentional dysregulation. Exploratory analysis suggests that other regions involved in emotional processing such as insula and ventral striatum also show a similar reduction in grey matter volume mirroring clinical disorders associated with emotional dysregulation. Our findings support the concept of continuous properties in psychiatric symptomatology.

SUBMITTER: Petrovic P 

PROVIDER: S-EPMC4927027 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

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Significant grey matter changes in a region of the orbitofrontal cortex in healthy participants predicts emotional dysregulation.

Petrovic Predrag P   Ekman Carl Johan CJ   Klahr Johanna J   Tigerström Lars L   Rydén Göran G   Johansson Anette G M AG   Sellgren Carl C   Golkar Armita A   Olsson Andreas A   Öhman Arne A   Ingvar Martin M   Landén Mikael M  

Social cognitive and affective neuroscience 20150615 7


The traditional concept of 'categorical' psychiatric disorders has been challenged as many of the symptoms display a continuous distribution in the general population. We suggest that this is the case for emotional dysregulation, a key component in several categorical psychiatric disorder constructs. We used voxel-based magnetic resonance imaging morphometry in healthy human subjects (n = 87) to study how self-reported subclinical symptoms associated with emotional dysregulation relate to brain  ...[more]

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