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Life with eight flagella: flagellar assembly and division in Giardia.

ABSTRACT: Flagellar movement in Giardia, a common intestinal parasitic protist, is crucial to its survival in the host. Each axoneme is unique in possessing a long, cytoplasmic portion as well as a membrane-bound portion. Intraflagellar transport (IFT) is required for the assembly of membrane-bound regions, yet the cytoplasmic regions may be assembled by IFT-independent mechanisms. Steady-state axoneme length is maintained by IFT and by intrinsic and active microtubule dynamics. Following mitosis and before their segregation, giardial flagella undergo a multigenerational division cycle in which the parental eight flagella migrate and reposition to different cellular locations; eight new flagella are assembled de novo. Each daughter cell thus inherits four mature and four newly synthesized flagella.

SUBMITTER: Dawson SC

PROVIDER: S-EPMC4927303 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature

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Life with eight flagella: flagellar assembly and division in Giardia.

Dawson Scott C SC House Susan A SA

Current opinion in microbiology 20100625 4

Flagellar movement in Giardia, a common intestinal parasitic protist, is crucial to its survival in the host. Each axoneme is unique in possessing a long, cytoplasmic portion as well as a membrane-bound portion. Intraflagellar transport (IFT) is required for the assembly of membrane-bound regions, yet the cytoplasmic regions may be assembled by IFT-independent mechanisms. Steady-state axoneme length is maintained by IFT and by intrinsic and active microtubule dynamics. Following mitosis and befo ...[more]

PMID: 20580308

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Dataset Information

Life with eight flagella: flagellar assembly and division in Giardia.

Publications

Life with eight flagella: flagellar assembly and division in Giardia.

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