Ontology highlight
ABSTRACT:
SUBMITTER: Nghiem PT
PROVIDER: S-EPMC4927341 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Nghiem Paul T PT Bhatia Shailender S Lipson Evan J EJ Kudchadkar Ragini R RR Miller Natalie J NJ Annamalai Lakshmanan L Berry Sneha S Chartash Elliot K EK Daud Adil A Fling Steven P SP Friedlander Philip A PA Kluger Harriet M HM Kohrt Holbrook E HE Lundgren Lisa L Margolin Kim K Mitchell Alan A Olencki Thomas T Pardoll Drew M DM Reddy Sunil A SA Shantha Erica M EM Sharfman William H WH Sharon Elad E Shemanski Lynn R LR Shinohara Michi M MM Sunshine Joel C JC Taube Janis M JM Thompson John A JA Townson Steven M SM Yearley Jennifer H JH Topalian Suzanne L SL Cheever Martin A MA
The New England journal of medicine 20160419 26
<h4>Background</h4>Merkel-cell carcinoma is an aggressive skin cancer that is linked to exposure to ultraviolet light and the Merkel-cell polyomavirus (MCPyV). Advanced Merkel-cell carcinoma often responds to chemotherapy, but responses are transient. Blocking the programmed death 1 (PD-1) immune inhibitory pathway is of interest, because these tumors often express PD-L1, and MCPyV-specific T cells express PD-1.<h4>Methods</h4>In this multicenter, phase 2, noncontrolled study, we assigned adults ...[more]