Dataset Information

Income and Markers of Immunological Cellular Aging.

ABSTRACT:

Objective

Socioeconomic disadvantage may contribute to poor health through immune-related biological mechanisms. We examined the associations between socioeconomic status, as measured by annual household income, and T-cell markers of aging, including the ratios of CD4 and CD8 effector cells to naïve cells (E/N ratio) and the CD4/CD8 T-cell ratio. We hypothesized that participants with a lower income would have higher E/N ratios and lower CD4/CD8 ratios compared with participants with a higher income, and that these associations would be partially mediated by elevated cytomegalovirus (CMV) IgG antibody levels, a virus implicated in aging and clonal expansion of T cells.

Methods

Data were from 79 individuals who participated in the population-based Detroit Neighborhood Health Study. We used linear regression to quantify the association between a $10,000 decrease in income and each ratio outcome.

Results

After adjustment for age, sex, race, smoking, medication use, and lifetime history of mental health conditions, lower income was associated with a 0.41 (95% confidence interval = 0.09-0.72) log-unit increase in the CD4 E/N ratio and a 0.20 (95% confidence interval = 0.02-0.39) log-unit increase in the CD8 E/N ratio. CMV immunoglobulin G antibody level partially mediated these associations.

Conclusions

Our study suggests that low socioeconomic status is associated with immunological aging as measured by the E/N ratio and that impaired immune control of CMV may partially mediate these associations.

SUBMITTER: Aiello AE

PROVIDER: S-EPMC4927391 | biostudies-literature | 2016 Jul-Aug

REPOSITORIES: biostudies-literature

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Publications

Income and Markers of Immunological Cellular Aging.

Aiello Allison E AE Feinstein Lydia L Dowd Jennifer B JB Pawelec Graham G Derhovanessian Evelyna E Galea Sandro S Uddin Monica M Wildman Derek E DE Simanek Amanda M AM

Psychosomatic medicine 20160701 6

<h4>Objective</h4>Socioeconomic disadvantage may contribute to poor health through immune-related biological mechanisms. We examined the associations between socioeconomic status, as measured by annual household income, and T-cell markers of aging, including the ratios of CD4 and CD8 effector cells to naïve cells (E/N ratio) and the CD4/CD8 T-cell ratio. We hypothesized that participants with a lower income would have higher E/N ratios and lower CD4/CD8 ratios compared with participants with a h ...[more]

PMID: 27187853

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Dataset Information

Income and Markers of Immunological Cellular Aging.

Objective

Methods

Results

Conclusions

Publications

Income and Markers of Immunological Cellular Aging.

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