Ontology highlight
ABSTRACT:
SUBMITTER: Filippone EJ
PROVIDER: S-EPMC4928035 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Clinical nephrology 20140701 1
Idiopathic membranous nephropathy (iMN) is a single-organ autoimmune disease characterized by subepithelial deposition of immune complexes containing IgG4 resulting in proteinuria, nephrotic syndrome, and, in some, end-stage renal disease. The pathogenesis involves a chronic IgG4 response against specific podocyte antigens which have now been at least partially defined in the neonatal, early childhood, and adult varieties. More has recently been learned about the genetic predisposition as well. ...[more]