Darwinolide, a New Diterpene Scaffold That Inhibits Methicillin-Resistant Staphylococcus aureus Biofilm from the Antarctic Sponge Dendrilla membranosa.
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ABSTRACT:
SUBMITTER: von Salm JL
PROVIDER: S-EPMC4928490 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
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Darwinolide, a New Diterpene Scaffold That Inhibits Methicillin-Resistant Staphylococcus aureus Biofilm from the Antarctic Sponge Dendrilla membranosa.
von Salm Jacqueline L JL Witowski Christopher G CG Fleeman Renee M RM McClintock James B JB Amsler Charles D CD Shaw Lindsey N LN Baker Bill J BJ
Organic letters 20160513 11
A new rearranged spongian diterpene, darwinolide, has been isolated from the Antarctic Dendroceratid sponge Dendrilla membranosa. Characterized on the basis of spectroscopic and crystallographic analysis, the central seven-membered ring is hypothesized to originate from a ring-expansion of a spongian precursor. Darwinolide displays 4-fold selectivity against the biofilm phase of methicillin-resistant Staphylococcus aureus compared to the planktonic phase and may provide a scaffold for the develo ...[more]
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