Ontology highlight
ABSTRACT:
SUBMITTER: Staveness D
PROVIDER: S-EPMC4928627 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Staveness Daryl D Abdelnabi Rana R Schrier Adam J AJ Loy Brian A BA Verma Vishal A VA DeChristopher Brian A BA Near Katherine E KE Neyts Johan J Delang Leen L Leyssen Pieter P Wender Paul A PA
Journal of natural products 20160222 4
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus showing a recent resurgence and rapid spread worldwide. While vaccines are under development, there are currently no therapies to treat this disease, except for over-the-counter (OTC) analgesics, which alleviate the devastating arthritic and arthralgic symptoms. To identify novel inhibitors of the virus, analogues of the natural product bryostatin 1, a clinical lead for the treatment of cancer, Alzheimer's disease, and HIV eradication, wer ...[more]