Dataset Information

Influence of cigarette smoking and inflammatory gene polymorphisms on glycated hemoglobin in the Japanese general population.

ABSTRACT:

Objective

Inflammation is closely involved in the development of type 2 diabetes, and cigarette smoking acts as potent inducer of inflammation. We therefore investigated interactions between inflammation-related gene polymorphisms and cigarette smoking on glycated hemoglobin (HbA1c) in the Japanese general population.

Method

We conducted a cross-sectional study using data collected from 2619 Japanese (1274 males and 1345 females) 40-69 years of age who participated in baseline survey of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study (2005-2008). Eight polymorphisms in seven genes (interleukin [IL]-1?, IL-2, IL-4, IL-8, IL-10, IL-13 and tumor necrosis factor-?) were determined using the Invader assay. The interactions of smoking and gene polymorphisms on HbA1c levels were analyzed using multiple linear and logistic regression models and analysis of covariance with adjustment for potential confounders.

Results

Among the eight polymorphisms, only one significant interaction was detected for IL-1? T-31C (P < 0.0001). Among the subjects carrying TT genotype, current heavy smokers (? 20 cigarettes/day) had higher HbA1c (5.83 [95% confidence interval 5.67-5.99] %) versus all other smoking status groups (never 5.49 [5.41-5.56] %, former 5.54 [5.43-5.65] %, current moderate [< 20 cigarettes/day] 5.50 [5.30-5.69] %), whereas such differences were not observed in the subjects with C allele. The logistic regression analyses regarding high-normal HbA1c levels showed a similar pattern of results.

Conclusion

Smoking status did not interact with any other inflammation-related polymorphisms except for IL-1? T-31C. Heavy smokers harboring the TT genotype of IL-1? T-31C polymorphism show a greater adverse effect of smoking on HbA1c levels among Japanese middle-aged subjects.

SUBMITTER: Nishida Y

PROVIDER: S-EPMC4929182 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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Publications

Influence of cigarette smoking and inflammatory gene polymorphisms on glycated hemoglobin in the Japanese general population.

Nishida Yuichiro Y Hara Megumi M Sakamoto Tatsuhiko T Shinchi Koichi K Kawai Sayo S Naito Mariko M Hamajima Nobuyuki N Kadota Aya A Suzuki Sadao S Ibusuki Rie R Hirata Akie A Yamaguchi Miwa M Kuriyama Nagato N Oze Isao I Mikami Haruo H Kubo Michiaki M Tanaka Hideo H

Preventive medicine reports 20160324

<h4>Objective</h4>Inflammation is closely involved in the development of type 2 diabetes, and cigarette smoking acts as potent inducer of inflammation. We therefore investigated interactions between inflammation-related gene polymorphisms and cigarette smoking on glycated hemoglobin (HbA1c) in the Japanese general population.<h4>Method</h4>We conducted a cross-sectional study using data collected from 2619 Japanese (1274 males and 1345 females) 40-69 years of age who participated in baseline sur ...[more]

PMID: 27419029

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Project description:Lifestyle including smoking, noise exposure with MP3 player and drinking alcohol are considered as risk factors for affecting hearing synergistically. However, little is known about the association of cigarette smoking with hearing impairment among subjects who carry a lifestyle without using MP3 player and drinking alcohol. We showed here the influence of smoking on hearing among Bangladeshi subjects who maintain a lifestyle devoid of using MP3 player and drinking alcohol. A total of 184 subjects (smokers: 90; non-smokers: 94) were included considering their duration and frequency of smoking for conducting this study. The mean hearing thresholds of non-smoker subjects at 1, 4, 8 and 12 kHz frequencies were 5.63 ± 2.10, 8.56±5.75, 21.06 ± 11.06, 40.79 ± 20.36 decibel (dB), respectively and that of the smokers were 7 ± 3.8, 13.27 ± 8.4, 30.66 ± 12.50 and 56.88 ± 21.58 dB, respectively. The hearing thresholds of the smokers at 4, 8 and 12 kHz frequencies were significantly (p<0.05) higher than those of the non-smokers, while no significant differences were observed at 1 kHz frequency. We also observed no significant difference in auditory thresholds among smoker subgroups based on smoking frequency. In contrast, subjects smoked for longer duration (>5 years) showed higher level of auditory threshold (62.16 ± 19.87 dB) at 12 kHz frequency compared with that (41.52 ± 19.21 dB) of the subjects smoked for 1-5 years and the difference in auditory thresholds was statistically significant (p<0.0002). In this study, the Brinkman Index (BI) of smokers was from 6 to 440 and the adjusted odds ratio showed a positive correlation between hearing loss and smoking when adjusted for age and body mass index (BMI). In addition, age, but not BMI, also played positive role on hearing impairment at all frequencies. Thus, these findings suggested that cigarette smoking affects hearing level at all the frequencies tested but most significantly at extra higher frequencies.

Dataset Information

Influence of cigarette smoking and inflammatory gene polymorphisms on glycated hemoglobin in the Japanese general population.

Objective

Method

Results

Conclusion

Publications

Influence of cigarette smoking and inflammatory gene polymorphisms on glycated hemoglobin in the Japanese general population.

Similar Datasets

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