Ontology highlight
ABSTRACT:
SUBMITTER: Hung MS
PROVIDER: S-EPMC4929302 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Hung Ming-Szu MS Chen I-Chuan IC You Liang L Jablons David M DM Li Ya-Chin YC Mao Jian-Hua JH Xu Zhidong Z Lung Jr-Hau JH Yang Cheng-Ta CT Liu Shih-Tung ST
Journal of cellular and molecular medicine 20160310 7
Cullin 4A (Cul4A) has been observed to be overexpressed in various cancers. In this study, the role of Cul4A in the growth and chemosensitivity in lung cancer cells were studied. We showed that Cul4A is overexpressed in lung cancer cells and tissues. Knockdown of the Cul4A expression by shRNA in lung cancer cells resulted in decreased cellular proliferation and growth in lung cancer cells. Increased sensitivity to gemcitabine, a chemotherapy drug, was also noted in those Cul4A knockdown lung can ...[more]