A Multi-Step miRNA-mRNA Regulatory Network Construction Approach Identifies Gene Signatures Associated with Endometrioid Endometrial Carcinoma.
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ABSTRACT:
SUBMITTER: Xiong H
PROVIDER: S-EPMC4929425 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
A Multi-Step miRNA-mRNA Regulatory Network Construction Approach Identifies Gene Signatures Associated with Endometrioid Endometrial Carcinoma.
Xiong Hanzhen H Li Qiulian Q Chen Ruichao R Liu Shaoyan S Lin Qiongyan Q Xiong Zhongtang Z Jiang Qingping Q Guo Linlang L
Genes 20160602 6
We aimed to identify endometrioid endometrial carcinoma (EEC)-related gene signatures using a multi-step miRNA-mRNA regulatory network construction approach. Pathway analysis showed that 61 genes were enriched on many carcinoma-related pathways. Among the 14 highest scoring gene signatures, six genes had been previously shown to be endometrial carcinoma. By qRT-PCR and next generation sequencing, we found that a gene signature (CPEB1) was significantly down-regulated in EEC tissues, which may be ...[more]
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