Ontology highlight
ABSTRACT:
SUBMITTER: Godin-Heymann N
PROVIDER: S-EPMC4929484 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Oncogene 20151012 25
Suppression of detachment-induced cell death, known as anoikis, is an essential step for cancer metastasis to occur. We report here that expression of KLF12, a member of the Kruppel-like family of transcription factors, is downregulated in lung cancer cell lines that have been selected to grow in the absence of cell adhesion. Knockdown of KLF12 in parental cells results in decreased apoptosis following cell detachment from matrix. KLF12 regulates anoikis by promoting the cell cycle transition th ...[more]