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Changes in autofluorescence based organoid model of muscle invasive urinary bladder cancer.


ABSTRACT: Muscle invasive urinary bladder cancer is one of the most lethal cancers and its detection at the time of transurethral resection remains limited and diagnostic methods are urgently needed. We have developed a muscle invasive transitional cell carcinoma (TCC) model of the bladder using porcine bladder scaffold and the human bladder cancer cell line 5637. The progression of implanted cancer cells to muscle invasion can be monitored by measuring changes in the spectrum of endogenous fluorophores such as reduced nicotinamide dinucleotide (NADH) and flavins. We believe this could act as a useful tool for the study of fluorescence dynamics of developing muscle invasive bladder cancer in patients. Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI.

SUBMITTER: Palmer S 

PROVIDER: S-EPMC4929632 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature

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Changes in autofluorescence based organoid model of muscle invasive urinary bladder cancer.

Palmer Scott S   Litvinova Karina K   Dunaev Andrey A   Fleming Stewart S   McGloin David D   Nabi Ghulam G  

Biomedical optics express 20160307 4


Muscle invasive urinary bladder cancer is one of the most lethal cancers and its detection at the time of transurethral resection remains limited and diagnostic methods are urgently needed. We have developed a muscle invasive transitional cell carcinoma (TCC) model of the bladder using porcine bladder scaffold and the human bladder cancer cell line 5637. The progression of implanted cancer cells to muscle invasion can be monitored by measuring changes in the spectrum of endogenous fluorophores s  ...[more]

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